Sassafras Southern Bistro

Sassafras Southern Bistro At Sassafras, we go above and beyond to make every guest feel at home with true Southern hospitality.

From hand-crafted cocktails and chef-inspired specials to house-made desserts, every detail is designed to create an unforgettable dining experience.

Shake things up—join us for Tequila Tuesday and $6 house margaritas made with our homemade sour mix at Sassafras!
04/07/2026

Shake things up—join us for Tequila Tuesday and $6 house margaritas made with our homemade sour mix at Sassafras!

Our salmon and lump blue crab brings fresh Atlantic salmon together with sweet crab and a lime cilantro beurre blanc, se...
01/01/2026

Our salmon and lump blue crab brings fresh Atlantic salmon together with sweet crab and a lime cilantro beurre blanc, served over creamy grits with sautéed asparagus. Bright, comforting, and full of coastal flavor at Sassafras.

From our kitchen to your table, thank you. We're proud to share that Sassafras Southern Bistro was voted Best Southern R...
01/01/2026

From our kitchen to your table, thank you. We're proud to share that Sassafras Southern Bistro was voted Best Southern Restaurant in Greenville's Best Readers 2025 Choice Awards by the Post and Courier!

From family dinners to milestone celebrations, Sassafras is where Greenville gathers. Our warm atmosphere and welcoming ...
11/26/2025

From family dinners to milestone celebrations, Sassafras is where Greenville gathers. Our warm atmosphere and welcoming team make every occasion feel like home. Let us host your next event—you bring the guests, we’ll take care of the rest!

Join us for dinner, drinks, and dessert at Sassafras tonight—the perfect way to unwind in the heart of downtown Greenvil...
11/21/2025

Join us for dinner, drinks, and dessert at Sassafras tonight—the perfect way to unwind in the heart of downtown Greenville.

Wednesday nights call for a little something to look forward to! Join us for Wine Wednesday—all bottles are half price (...
11/19/2025

Wednesday nights call for a little something to look forward to! Join us for Wine Wednesday—all bottles are half price (up to $40 off). The perfect midweek excuse to slow down and savor your favorite glass.🍷

Pan-seared perfection. Our sea scallops are topped with lobster cream sauce and served with creamy parmesan risotto and ...
11/14/2025

Pan-seared perfection. Our sea scallops are topped with lobster cream sauce and served with creamy parmesan risotto and sautéed spinach—that’s dinner done right.

Southern flavor, Greenville charm, and a warm welcome waiting just inside the door. Join us for dinner at Sassafras. 🍽️ ...
11/12/2025

Southern flavor, Greenville charm, and a warm welcome waiting just inside the door. Join us for dinner at Sassafras. 🍽️

Address

103 North Main Street, Suite 107
Main Street, SC
29601

Opening Hours

Monday 5pm - 9pm
Tuesday 5pm - 9pm
Wednesday 5pm - 9pm
Thursday 5pm - 9pm
Friday 5pm - 9:30pm
Saturday 4:30pm - 9:30pm

Telephone

+18642355670

Website

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